Genizer GJE-10mL ジャケット付きリポソーム押出装置 (10mL, 4kg, 5mL)

Sample Size: 10mL

Cooling: Jacketed

Dimensions: 23cm×13cm×25cm

Weight: 4kg

Min. Sample Size: 5mL

Application: Liposome formulation up to production scale

Max. Pressure: 80 psi-500 psi

Max. Temp.: 80ºC (176ºF)

Power Type: Compressed gas

Nano-membrane: Track-etched membrane

Cleaning: Flush to clean/CIP/SIP

Sterilization: Whole unit autoclavable

Standard Features

Parts

1) Liposome Jacketed Extruder 

2) 10 pieces of 100nm membrane

Feed Reservoir: Temperature-controled jacketed cylinder

Inlet Type: 1/4" high pressure coupling

Outlet Type: 1/4" high pressure coupling

Nitrogen Tubing: G5/8" - 14 TPI BSP inlet nitrogen high pressure soft tubing; adaptor with 3/8-inch male NPT and 1/4-inch female flare outlet

Nano Membrane: 100nm track-etched polycarbonate membrane

Compatibility: Some parts are compatible with Lipex in Northern Lipids

Product Material: 316L stainless steel, NBR  or FKM

Material Standard: Sanitary grade; compliant with FDA and GMP sanitary standards

Including:

- High-pressure nitrogen tubing G5/8

- Adaptor with 3/8 inch male NPT and 1/4 inch

- Laser disc

- Extra seal pack 

- Extra outlet plastic tube, luer ends

Genizer Lipid Extrusion Methods

Liposomes have grown as an important biomedical carrier system. One of the most critical factors influencing the performance of liposome is particle size. High-pressure homogenization, extrusion and sonication are methods for reducing liposome size. The extrusion technique is a reasonably mild and quick procedure among them.

Genizer liposome extrusion line includes jacketed liposome extruders, online extruders and hand driven liposome extruder

Genizer Jacketed Liposome Extruders:

The Genizer Jacketed Liposome Extruder utilizes a nitrogen gas cylinder to force a drug, protein or gene liposome suspension via a track-etched membrane with a predetermined pore size; generally, 5–10 passes are enough to create a sample with consistent liposome size. The Genizer Jacketed Liposome Extruders are designed to produce uniform unilamellar liposomes and lipopolyplexes with minimal dead volume.

Genizer Online Liposome Extruders:

The Genizer Online Extruder combines with a high pressure homogenizer, which can help decrease the number of passes required to attain a perfect liposome size distribution and desired particle sizes since the homogenizer system (diamond interaction chamber) will help pre-treat the liposome sample to the nanoscale.

Features:

Capacity of the extruder barrel: 25/200/1000mL, 8/20L

Cooling: jacketed thermo barrel

Material: 316L stainless steel, NBR or Viton

Spares: O-rings, collection silicone tubing

Including: Large pore support screen, laser micro pore disc

Genizer Hand Driven Liposome Extruders (Mini scale):

The Genizer HandExtruder is a low-cost micro liposome extrusion tool. Two gas-tight syringes, an extrusion body and a stabilizing block are included.

It facilitates liposome preparation with hands-on operation. The user can gradually push the plunger of the filled syringe to drive the sample through the filter membrane within the extruder body, and then gently push the plunger to return the sample to the original syringe. To get a sample with uniform liposome sizes, the user can repeat these two steps five to ten times.

Features:

Catalog No: HandExtruder — 1 mL; HandExtruder — 2.5 mL

Cooling: jacketed thermo barrel

Mini sample size: 0.25 mL

Spares: O-rings

Feed and Collection: Gas-tight syringe, Hamilton

Datasheet